Science Daily, July 18, 2022
In the largest study of its kind, researchers have found that HDM/SCT produces prolonged survival with improved safety in patients with AL amyloidosis. Additionally, they have for the first time developed a predictive score to assess event free survival following stem cell transplantation. Event-free survival is defined as the time between stem cell transplantation and initiation of next line of therapy or death, whichever occurs first.
AL amyloidosis is a life-threatening disease related to bone marrow cancer, multiple myeloma. It is caused when a person’s antibody-producing white blood cells (i.e. plasma cells) do not function properly and generate abnormal protein which misfolds to form amyloid fibrils and deposits made of components of antibodies called light chains, which then deposit in various organs of the body.
For some and highly selected patients, treatment includes high-dose chemotherapy (melphalan) and autologous (one’s own) stem cell transplantation (HDM/SCT).
In the largest study of its kind, researchers from the Boston University/Boston Medical Center Amyloidosis Center have found that HDM/SCT produces prolonged survival with improved safety in patients with AL amyloidosis. Additionally, they have for the first time developed a predictive score to assess event free survival following stem cell transplantation. Event-free survival is defined as the time between stem cell transplantation and initiation of next line of therapy or death, whichever occurs first.
“This data highlights a continued role for time tested HDM/SCT in the treatment paradigm of transplant-eligible patients with AL amyloidosis. This treatment, first developed here at BU/BMC in the 1990s, leads to long term survival especially for those who achieve a complete hematologic response after SCT,” says corresponding author Vaishali Sanchorawala, MD, director of the Boston University/Boston Medical Center Amyloidosis Center.
The researchers reviewed collected data from a prospectively maintained database of patients with AL amyloidosis consecutively treated with HDM/SCT between July 1994 and September 2021.They found that hematologic complete remission (CR) was achieved in 39 percent of patients with a median overall survival of 15 years with 30 percent of these patients survived greater than 20 years.
“The risk of future hematologic relapse was also low (five percent) amongst patients with a sustained hematologic CR for 15 years, suggesting that the majority of patients who reach this milestone may be operationally cured by HDM/SCT,” added Sanchorawala.
The researcher also developed a prognostic score for event free survival which incorporated measuring the patients’ light chain levels and bone marrow plasma cell percentage. Patients with low-risk (0 factors), intermediate-risk (1 factor), and high-risk (2 factors) disease had median event-free survival estimate of 5.3, 2.8 and 1 years, respectively.
These findings appear online in the American Journal of Hematology.
Joshua N. Gustine, Andrew Staron, Raphael E. Szalat, Lisa M. Mendelson, Tracy Joshi, Frederick L. Ruberg, Omar Siddiqi, Deepa M. Gopal, Camille V. Edwards, Andrea Havasi, Michelle Kaku, K. H. Vincent Lau, John L. Berk, J. Mark Sloan, Vaishali Sanchorawala. Predictors of hematologic response and survival with stem cell transplantation in AL amyloidosis: A 25‐year longitudinal study. American Journal of Hematology, 2022; DOI: 10.1002/ajh.26641
Source: Boston University School of Medicine